Models Considered
Hours of Research
Researchers Consulted
Reviews Analyzed

The Best Enzymatic Cleaners

Enzymatic Cleaners are essential in keeping a clean and hygienic home and ensure that you and your family are always healthy. When you have stubborn stains, grimes or even smells that are hard to remove, an enzymatic cleaner is perfect because they can be tough on those stains but gentle on most surfaces without damaging it unlike traditional chemical cleaners.

Buyers Guide

  1. When should I use an enzymatic cleaner?

    Answer: Enzymatic cleaners work best for tough stains and odors caused by pets as they are usually environmentally friend and toxic-free.

  2. How does an enzymatic cleaner work?

    Answer: It breaks down the stains at a molecular level basically eating away the stain and any associated smell that comes from it.

  3. What should I look for in an enzymatic cleaner?

    Answer: First, you will want to know how strong or gentle it is on fabrics. Make sure to get one that also works on the surface you want to use the stain or odor. Lastly, check what the enzymatic cleaner is good for – is it for dogs, cats, animals or humans stains?

Our Top Picks


Nature’s Miracle Urine Destroyer Stain and Residue Eliminator

  • Great for Pet Stains
  • Odor Eliminator
  • Smells Great

Probably one of the hardest stains to take out is urine stains and specifically animal urine. So if you are taking care of pets or even babies, you know how the stain can be hard to remove and the smell tends to stick. This is where Nature’s Miracle Urine Destroyer Stain and Residue Eliminator comes in. It’s tough on any animal urine or stains as the cleaner will slowly take out the stain and any accompanying smells. What’s great is it’s not only for animal stains but can be used for cleaning clothing or even underwear. But be careful with the smell of the cleaner itself as it’s not for everyone. The strong scent can be overwhelming to migraine sufferers. However, if you’re looking for something that will take out animal urine and stains, then this is the cleaner for you. Check out this YouTube review for more information.


Zero Odor® Pet Odor Eliminator

  • Does not mask or cover up odors with fragrances
  • Permanently eliminates all existing odors
  • Works in the air and on surfaces
  • Non-toxic, Non-allergenic, and Biodegradable

Zero Odor’s Odor Eliminator products contain a fragrance-free molecular technology that chemically and physically changes odor molecules to permanently become odorless. This product eliminates the toughest and most stubborn pet odors while leavings no unwanted fragrance behind. Zero Odor Pet can be sprayed in the air or on surfaces, and is perfect for pet bedding, flooring, furniture, artificial turf, grass, crates, and more. Traditional enzyme-based products have living organisms that attempt to “eat” odor causing bacteria. Depending on the source and strength of the odor this process can be slow, and ineffective. Zero Odor contains no enzymes, and works through a molecular bonding process in which Zero Odor renders odor molecules odorless. Despite its unparalleled effectiveness, Zero Odor is non-allergenic, non-toxic, and safe to use around people and pets.


Professional Strength Stain & Odor Remover by Pawstruck

  • Professional Strength, Makes Stains Disappear
  • Natural, Non-Toxic, and Biodegradable
  • Made in the USA with Safe Ingredients
  • Amazing Lemongrass Scent

Pawstruck’s Odor Eliminator flat out works! It eradicates odors permanently and makes stains disappear. It’s made from a proprietary enzyme-based blend of natural ingredients making it safe for your pets and your carpet, upholstery, hardwood, tile, and more. Use it to remove stains and smells from urine, vomit, blood, wine, waste, and many other messes. The natural, biodegradable enzyme formula is more effective than most harsh cleaning agents because it actually breaks down odor and stain causing residues rather than masking them.


Simple Green® Bio Dog Stain & Odor Remover

  • Use on pet soils, dirt, and more
  • Utilizes beneficial bacteria and enzymes to clean
  • Tackles new messes and stubborn old soils
  • Combats bad odors on contact

Simple Green Bio Dog utilizes safe bacteria to break down and digest soils, ultimately eliminating them at the source, instead of just temporarily covering them up. It permanently dissolves stains and odors from urine, feces, vomit, scent-markings, dirt, and more, leaving behind nothing but a clean, fresh scent. Bio Dog can be used as a spot cleaner, in carpet cleaning machines, and as a laundry pre-treat on porous surfaces around the home such as carpet, rugs, pet bedding, upholstery, and clothing. Another huge benefit is that it discourages pets from revisiting spots and remarking them over and over again.


NonScents Carpet Odor Eliminator – Pet Carpet Deodorizer

  • Perfect for Dog and Cat Urine
  • Sensitive
  • Easy to use

Another enzymatic cleaner that’s great for pet stain and odor removal is the NonScents Pet Odor & Stain Remover. It’s perfect for both dog and cat urine and will outperform most home remedies. The nice thing is that the cleaner itself is fragrance free so there’s no flowery or overpowering scent. It’s the great for carpets, litter bins and rugs. It also does not discolor fabric either. While it doesn’t have any strong fragrances, you can still smell and feel like bleach which may not be good for those who have asthma. The cleaner deals with the stain at a molecular level which is why it also eliminates the smell it creates as well. For more details on this cleaner, check out this YouTube review.


Black Diamond Stoneworks Ur-in Control

  • Biodegradable
  • Great for Pets
  • Works on Many Surfaces

Now, with most cleaners, it’s good for one or few kinds of stains. The Black Diamond Stoneworks Ur-in Control is great multi-purpose cleaner that works to removing most animal and human stains and smells. It also works well on a many surfaces such as carpets, furniture, mattresses, grout and pet bedding, and even concrete. This cleaner is biodegradable so you don’t have to worry that you’ll be dumping chemicals down the drain. It’s very useful for odor elimination and one of the best urine neutralizer. It does have a strong smell and doesn’t work on removing old dated smells. While it works on most surfaces, it does have a hard time working on hardwood. This non-toxic cleaner is safe to be used around children and pets and outperforms most other cleaners on the market. This YouTube review will let you know more about this product.


FurryFreshness Premium Pet Stain & Smell Remover

  • Great for Pets
  • Wont harm plants
  • Biodegradable
  • No Harsh Chemicals

The FurryFreshness Premium Pet Stain and Smell Remover is another enzymatic cleaner that people are calling a miracle cleaner as it removes stains like it never was there. Unlike traditional chemical cleaners, this cleaner is completely environmentally safe and non-toxic. So it’s safe to use around children, pets and even around plants. It works well it taking out the toughest stains without leaving any odor or smell. Make sure to apply the stain remove as instructed and rinse thoroughly as some stains may come back. The great thing about this stain remove is that it does not have harsh chemicals or bleach. For more information, you may take a look at this YouTube review.

There are definitely many enzymatic cleaners out in the market, they are great for removing tough stains and odors that come from pets. Most are environmentally friendly and non-toxic to pets and children. So if you have problems with tough stains and odors, then these enzymatic cleaners are what you should be using for your home.