Models Considered
Hours of Research
Researchers Consulted
Reviews Analyzed

Best Pain Relieving Creams with Lidocaine

Lidocaine is a medication used to cause temporary numbness of the skin. It is found in some pain relieving creams because it helps decrease discomfort, swelling, itching, and pain. We reviewed dozens of pain relieving creams with lidocaine to find the best of the best.

You might be looking for a topical numbing agent for a number of reasons including needle injections, tattooing, body piercing, laser tattoo removal, laser hair removal, body waxing, and other dermatological procedures. Lidocaine derived pain relieving creams work by blocking the pain signal sent by the nerve endings on the skin. Maybe you’ve burned yourself or have pain that you wish to numb on your skin for a whole myriad of reasons – to alleviate discomfort, many people apply topical pain relief creams on the sore area. If you want to get maximum numbing power, look to topical creams with lidocaine.

Buyers Guide

  1. Do pain relieving creams with lidocaine work?

    Answer: Yes. Being a local anesthetic, lidocaine temporarily blocks nerve signals in the body. Because of its numbing effects, it effectively reduces pain and discomfort caused by numerous factors.

  2. Are pain relieving creams with lidocaine safe?

    Answer: When used sparingly and as directed, topical pain relieving creams with lidocaine are generally safe. However, too much skin-numbing cream can cause serious side effects, such as seizures and comas.

  3. How long does it take for pain relieving creams with lidocaine to work?

    Answer: Pain relieving creams with lidocaine take about 90 seconds to start working, and their effects last about 20 minutes.

Our Top Picks


Dr. Numb Topical Numbing Cream

  • FDA Approved
  • 5% lidocaine
  • Non-invasive
  • Hypoallergenic

Dr. Numb is our top pick – temporarily reduce discomfort with this top of the shelf pain relieving cream. It contains 5% lidocaine which produces short-term numbness of the skin and its surrounding tissues. It has a rapid onset of action of 10 to 15 minutes, and lasts up to 4 hours. This OTC topical anesthetic cream relieves pain associated with aesthetic procedures like laser treatments and hair removal, medical procedures like insulin shots and glucose tests, and skin conditions like abrasions and minor cuts. It is may be reapplied, as necessary, to prolong the numbness and does not cause irritation of tissues and nerves. Applicable to all skin types, it is hypoallergenic and a pleasure to use!


Icy Hot Pain Relief Cream

  • With lidocaine and menthol
  • 2.7 ounces
  • Fast acting
  • Long lasting

Numb away soreness with this 2.7-ounce tube of pain relieving cream. It contains lidocaine and menthol that work together to desensitize aggravated nerves and relieve minor discomfort associated with foot pain, back pain, muscle pain, knee pain, and arthritis pain. It penetrates the skin and nerves in just minutes, giving you fast relief that lasts for hours. This formula temporarily alleviates backaches, strains, sprains, bruises, and cramps without leaving any greasy feel. To use, simply apply the cream to the affected area every 6 to 8 hours, and do not exceed 3 applications in a 24-hour period.


Aspercreme Maximum Strength Pain Relief Cream

  • 4% lidocaine
  • 4.7 ounces
  • Odor free
  • No irritation

Get fast-acting relief with this 4.7-ounce tube of pain relieving cream. It contains 4% lidocaine that targets pain receptors to numb away minor discomfort with no irritation or burning sensation. It quickly penetrates the skin to provide relief that lasts for hours, and starts working in minutes to target pain at the source. This non-greasy cream has no discernable smell, so it discreetly blocks discomfort. It works for both joints and muscles, alleviating lower back pain, arthritis, muscle strains, knee pain, shoulder pain, and foot pain.


Salonpas Lidocaine Pain Relieving Cream

  • 4% lidocaine
  • Fast acting
  • Maximum strength
  • 10% benzyl alcohol

Desensitize aggravated nerves with this 3-ounce tube of pain relieving cream. It contains 2 powerful anesthetics that effectively calm the nerves for hours: it has 4% lidocaine which is the maximum strength you can buy without a prescription, and it has 10% benzyl alcohol which numbs nerves fast. Together, these 2 medicines provide temporary relief of pain on the back, neck, shoulders, knees, and elbows. To use, simply clean and dry the affected area, then apply this topical cream not more than 3 to 4 times daily.


Everyday Medical Numbing Cream

  • 5% lidocaine
  • Topical
  • Deep penetration
  • Fast acting

Target pain at the source with this pain relieving cream. It contains the maximum dosage of lidocaine allowed by the FDA so you get effective and fast numbing results. It also contains natural and soothing ingredients such as clove oil, aloe vera, tea tree oil, and jojoba. This topical cream temporarily blocks the pathway of pain signals along the nerves, eliminating discomfort caused by tattoos, piercings, cosmetic sessions, electrolysis, microblading, and hemorrhoids. It has a deep-penetrating formula that works in just 15 to 30 minutes to ensure a pain-free session that lasts up to 4 hours. This anesthetic is paraben free, chemical free, and never tested on animals.


Medinumb Lidocaine Numbing Cream

  • 56 grams
  • 4% lidocaine
  • Fast acting
  • Water-based formulation

Block discomfort with this 56-gram tube of pain relieving cream. It contains 4% lidocaine and 3 penetrating botanicals that work well together to soothe the skin, reduce swelling, and alleviate pain temporarily. It desensitizes the skin’s pain receptors, providing you with 2 hours of relief. This topical anesthetic has been specifically formulated to be non-oily, leaving no stains on clothing. It provides numbing results for those who have undergone painful procedures like tattoos, piercings, hair removal, waxing, and injections.

While these pain relieving creams with lidocaine are proven to provide temporary relief from discomfort, it is still recommended to read and follow all directions on the product package before self-treating. If you have any questions, consult your pharmacist.